April 21, 2017
new journal - Alzheimer's & Dementia - The Journal of the Alzheimer's Association
Volume 13, Issue 2, p103-200
Age of onset of hypertension and risk of dementia in the oldest-old: The 90+ Study
Glucose level decline precedes dementia in elderly African Americans with diabetes
Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans
Mild cognitive impairment and risk of depression and anxiety: A population-based study
Many people with mild cognitive impairment (MCI) suffer from concomitant depression or anxiety. Whether MCI increases the risk of future depression or anxiety is unknown.
In the Rotterdam Study, cross-sectional (n = 4168) and longitudinal associations (n = 2967) of MCI with Diagnostic and Statistical Manual of Mental Disorders—depressive and anxiety disorders—were assessed (2002–2005 to 2009–2011).
MCI is a risk factor for dementia and for depressive and anxiety disorders, suggesting common pathological pathways for cognitive and psychiatric outcomes.
Association of blood lipids with Alzheimer's disease: A comprehensive lipidomics analysis
mTOR and neuronal cell cycle reentry: How impaired brain insulin signaling promotes Alzheimer's disease
Mediterranean diet, micronutrients and macronutrients, and MRI measures of cortical thickness
The Mediterranean diet (MeDi) is associated with reduced risk of cognitive impairment, but it is unclear whether it is associated with better brain imaging biomarkers.
Among 672 cognitively normal participants (mean age, 79.8 years, 52.5% men), we investigated associations of MeDi score and MeDi components with magnetic resonance imaging measures of cortical thickness for the four lobes separately and averaged (average lobar).
Higher MeDi score was associated with larger frontal, parietal, occipital, and average lobar cortical thickness. Higher legume and fish intakes were associated with larger cortical thickness: legumes with larger superior parietal, inferior parietal, precuneus, parietal, occipital, lingual, and fish with larger precuneus, superior parietal, posterior cingulate, parietal, and inferior parietal. Higher carbohydrate and sugar intakes were associated with lower entorhinal cortical thickness.
In this sample of elderly persons, higher adherence to MeDi was associated with larger cortical thickness. These cross-sectional findings require validation in prospective studies.
Calcium Hypothesis of Alzheimer's disease and brain aging: A framework for integrating new evidence into a comprehensive theory of pathogenesis
Perspective on the calcium dyshomeostasis hypothesis in the pathogenesis of selective neuronal degeneration in animal models of Alzheimer's disease
Recommended cognitive outcomes in preclinical Alzheimer's disease: Consensus statement from the European Prevention of Alzheimer's Dementia project
Perspective on calcium and Alzheimer's disease