April 21, 2017

new journal - Alzheimer's & Dementia - The Journal of the Alzheimer's Association


These articles and  resources are available for loan to members of AANSW - if you would like to reserve them please email the Library on nsw.library@alzheimers.org.au 

February 2017
Volume 13, Issue 2, p103-200

Featured Articles

Age of onset of hypertension and risk of dementia in the oldest-old: The 90+ Study
p103–110

Glucose level decline precedes dementia in elderly African Americans with diabetes
p111–118

Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans
p119–129

Mild cognitive impairment and risk of depression and anxiety: A population-based study

Abstract
Introduction
Many people with mild cognitive impairment (MCI) suffer from concomitant depression or anxiety. Whether MCI increases the risk of future depression or anxiety is unknown.
Methods
In the Rotterdam Study, cross-sectional (n = 4168) and longitudinal associations (n = 2967) of MCI with Diagnostic and Statistical Manual of Mental Disorders—depressive and anxiety disorders—were assessed (2002–2005 to 2009–2011).
Discussion
MCI is a risk factor for dementia and for depressive and anxiety disorders, suggesting common pathological pathways for cognitive and psychiatric outcomes.
p130–139

Association of blood lipids with Alzheimer's disease: A comprehensive lipidomics analysis
p140–151

mTOR and neuronal cell cycle reentry: How impaired brain insulin signaling promotes Alzheimer's disease
p152–167

Mediterranean diet, micronutrients and macronutrients, and MRI measures of cortical thickness
Abstract
Introduction
The Mediterranean diet (MeDi) is associated with reduced risk of cognitive impairment, but it is unclear whether it is associated with better brain imaging biomarkers.
Methods
Among 672 cognitively normal participants (mean age, 79.8 years, 52.5% men), we investigated associations of MeDi score and MeDi components with magnetic resonance imaging measures of cortical thickness for the four lobes separately and averaged (average lobar).
Results
Higher MeDi score was associated with larger frontal, parietal, occipital, and average lobar cortical thickness. Higher legume and fish intakes were associated with larger cortical thickness: legumes with larger superior parietal, inferior parietal, precuneus, parietal, occipital, lingual, and fish with larger precuneus, superior parietal, posterior cingulate, parietal, and inferior parietal. Higher carbohydrate and sugar intakes were associated with lower entorhinal cortical thickness.
Discussion
In this sample of elderly persons, higher adherence to MeDi was associated with larger cortical thickness. These cross-sectional findings require validation in prospective studies.
p168–177

Review Article

Calcium Hypothesis of Alzheimer's disease and brain aging: A framework for integrating new evidence into a comprehensive theory of pathogenesis

p178–182.e17

Perspectives

Perspective on the calcium dyshomeostasis hypothesis in the pathogenesis of selective neuronal degeneration in animal models of Alzheimer's disease

p183–185


Recommended cognitive outcomes in preclinical Alzheimer's disease: Consensus statement from the European Prevention of Alzheimer's Dementia project

p186–195
Lette

Perspective on calcium and Alzheimer's disease

p196–197

No comments:

Latest headlines from Alzheimer's News

Alzheimer's News