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September 04, 2014
American Journal of Alzheimer's Disease and Other Dementias - August 2014
may result from low-grade inflammation of the brain, and the characteristic
amyloid β may be a protective response. Epidemiological observation indicates
that long-term oral administration of nonsteroidal anti-inflammatory drugs
(NSAIDs) such as ibuprofen to patients having rheumatoid arthritis results in
reduced risk and delayed onset of Alzheimer's disease. However, oral ibuprofen,
flurbiprofen, and other NSAIDs are not an effective treatment.
A Literature Review of Frontotemporal Dementia and
There is a growing
body of research on Alzheimer’s disease and driving, but much less is known
about less common dementias, such as frontotemporal dementia (FTD). The purpose
of this study was to review the empirical literature about FTD and driving.
Role of Medium Chain Triglycerides (Axona®) in
the Treatment of Mild to Moderate Alzheimer’s Disease
Alzheimer’s disease (AD) with acetylcholinesterase inhibitors or
N-methyl-D-aspartate (NMDA) receptor antagonists provides symptomatic relief
but do not prevent its progression. Thus, additional approaches aimed at
slowing the progression of the disease have been investigated. Reports
detailing reduced brain glucose metabolism in the early stages of AD led to the
hypothesis that alternate energy sources aimed at increasing neuronal
metabolism may protect neurons and thus benefit patients with AD. Medium-chain
triglycerides (MCTs) are metabolized to ketone bodies that serve as an
alternative source of energy for neurons.
The Potential Role of Chemokines in Alzheimer’s Disease
(AD) is a neurodegenerative disorder and leading cause of dementia, which
begins with impaired memory. The neuropathological hallmarks of AD include
destructive alterations of neurons by neurofibrillary tangles, neuritic amyloid
plaques, and neuroinflammatory process in the brain. Chemokines have a major
role in inflammatory cell attraction and glial cell activation and/or modulation
in the central nervous system.
Impact of Noncaregiving-Related Stressors on Informal
Background: Caregivers of persons with dementia are
stressed. Stressors not related to care recipients’ needs impact caregiver
outcomes, yet are seldom reported. The purpose of this study was to report the
most stressful events experienced by spouse caregivers of older adults with
Alzheimer s disease during a 6-month period.
A Novel Presenilin 1 Mutation in Early-Onset Alzheimer’s
Disease With Prominent Frontal Features
disease (AD) is a rare disorder involving known autosomal dominant mutations in
the amyloid precursor protein and presenilin (PSEN) 1 and 2. Here, we present a
case of early-onset AD with prominent frontal features associated with a novel deletion
of codon 40 in the PSEN1 gene. Serial brain magnetic resonance imaging and 18F
florbetapir imaging show prominent involvement of the frontal lobes,
corresponding with the clinical presentation. This case report illustrates a
possible link between a novel PSEN1 mutation and frontal variant AD.
More Education May Limit Disability and Extend Life For
People With Cognitive Impairment
associated with longer life and less disability. Living longer increases risks
of cognitive impairment, often producing disability. We examined associations
among education, disability, and life expectancy for people with cognitive
impairment, following a 1992 cohort ages 55+ for 23 063 person-years (Panel
Study of Income Dynamics, n = 2165).
Medical Resource Value Appraisal for Leucojum aestivum in
In this study, we
investigate the medical and economical value of Leucojum aestivum. Leucojum aestivum contains
the alkaloid galanthamine, which is one of the main active substances in
Reminyl, a commonly used drug for the treatment of Alzheimer’s disease (AD).
Gastritis May Boost Odds of Dementia
Introduction: Given the high prevalence of dementia and
its devastating consequences, identifying risk factors for dementia is a public
health priority. The present study aims to assess whether gastritis increases
the odds of dementia.
Conclusions: The findings from this population-based
observational study showing evidence that gastritis may increase the risk of
dementia provide avenue for further inquiries into dementia.
Affect Balance and Relationship With Well-Being in
Nursing Home Residents With Dementia
The purpose of this
exploratory study was to determine whether the balance of positive to negative
affect can discriminate states of well-being in nursing home residents with dementia
and whether affect balance is associated with activity engagement
Effects of Multisensory Stimulation on a Sample of
Institutionalized Elderly People With Dementia Diagnosis
A Controlled Longitudinal Trial
Long-term effects of
multisensory stimulation were assessed using a “Snoezelen” room on older
residents with dementia. Thirty patients were randomly assigned to 3 groups:
multisensory stimulation environment (MSSE) group, individualized activities
(activity) group, and control group. The MSSE and activity groups participated
in two 30-minute weekly individualized intervention sessions over 16 weeks.
Magnetic Resonance Spectroscopy Study of Amnestic Mild
Cognitive Impairment and Vascular Cognitive Impairment With No Dementia
cognitive impairment (aMCI) and vascular cognitive impairment with no dementia
(VCIND) are highly predictive of Alzheimer’s disease and vascular dementia. In
this study, a 2-dimensional magnetic resonance spectroscopy was performed in 25
patients with aMCI, 28 patients with VCIND, and 32 normal controls (NCs). The
concentrations of N-acetyl aspartate (NAA), choline (Cho), myoinositol (MI),
and creatine (Cr) were measured, and their ratios were calculated.