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July 31, 2014
Alzheimer's Disease and Associated Disorders - April/June 2014
The Red Cell Distribution Width
and Anemia in Association With Prevalent Dementia
The red cell distribution
width (RDW), a measure of anisocytosis, independently predicts cardiovascular
disease outcomes and chronic disease mortality. Little is known about the RDW,
or the interplay between RDW and anemia, in relation to dementia risk. We
evaluated the association between the RDW and prevalent dementia, overall and
by anemia status, among 2556 community-dwelling older adults participating in
the Chicago Health and Aging Project.
Cerebral Microbleeds and
Cognition: The Epidemiology of Dementia in Singapore Study
Cerebral microbleeds (CMBs)
are considered to be a novel marker of cerebral small vessel disease. However,
the link with cognitive impairment remains unclear. We investigated whether
CMBs—independent of other traditional markers of cerebral small vessel disease—are
related to cognition. Chinese subjects from the population-based Singapore
Chinese Eye Study, who failed an initial cognitive screening and were recruited
into the ongoing Epidemiology of Dementia in Singapore Study, underwent
neuropsychological testing and 3 T brain magnetic resonance imaging.
How Well Do MCI Criteria Predict
Progression to Severe Cognitive Impairment and Dementia?
The International Working
Group (IWG) criteria for mild cognitive impairment have variable utility in
predicting progression to dementia, partly depending on the setting. We
explored an empiric approach to optimize the criteria and cutoff points in a
The Effect of APOE ε4 Allele on
Cholinesterase Inhibitors in Patients With Alzheimer Disease: Evaluation of the
Feasibility of Resting State Functional Connectivity Magnetic Resonance Imaging
This work is to determine
whether apolipoprotein E (APOE) genotype modulates the effect of
cholinesterase inhibitor (ChEI) treatment on resting state functional
connectivity magnetic resonance imaging (rs-fcMRI) in patients with Alzheimer
disease (AD). We retrospectively studied very mild and mild AD participants who
were treated (N=25) or untreated (N=19) with ChEIs with respect to rs-fcMRI
measure of 5 resting state networks (RSNs): default mode, dorsal attention
(DAN), control (CON), salience (SAL), and sensory motor.
Medication Adherence in Patients
With Dementia: An Austrian Cohort Study
Sustained treatment with
effective doses of cholinesterase inhibitors or memantine is crucial to
transfer treatment effects in dementia. Numerous studies, with often small
samples sizes, describe low adherence rates. The purpose of current study was
to examine the medical adherence of antidementia therapy in Austria.
Gene-Environment Interaction of
Body Mass Index and Apolipoprotein E ε4 Allele on Cognitive Decline
Genetic variation alone may
not account for common chronic disease susceptibility. Rather, an interaction
between genetic and environmental factors may clarify the underlying disease
mechanism. Hence, we tested whether body mass index (BMI) modified the genetic
association of the apolipoprotein E ε4 allele with cognitive decline. The data
came from a longitudinal population-based sample of 4055 participants
interviewed at 3-year intervals from 1993 to 2012.
A Complex Association of ABCA7
Genotypes With Sporadic Alzheimer Disease in Chinese Han Population
Recently, a large
genome-wide association study has revealed that polymorphism of alleles and
genotypes in rs3,764,650 within ABCA7 gene is associated with Alzheimer
disease in whites. We conducted a case-control study to investigate whether
these susceptible genetic variants are risk factors for sporadic Alzheimer
disease (SAD) in Chinese Han population.
Sleep Habits in Mild Cognitive
We explored the
relationship between sleep disturbances and mild cognitive impairment (MCI) in
community-dwelling seniors. Recent evidence suggests that sleep habits are
differentially compromised in different subtypes of MCI, but the relationship
between sleep disruption and MCI remains poorly understood.
The Mild Cognitive Impairment
Stage of Dementia With Lewy Bodies and Parkinson Disease: A Comparison of
Recent studies have
demonstrated that structural and pathologic changes are more severe in patients
with dementia with Lewy bodies (DLB) than in those with Parkinson disease with
dementia (PDD). We investigated neuropsychological characteristics of patients
with mild cognitive impairment (MCI) stage of DLB (DLB-MCI) and PD (PD-MCI)
based on the hypothesis that the pathologic differences between DLB and PDD can
influence cognitive profiles in the MCI stage of these diseases.
Comparison of 2 Informant
Questionnaire Screening Tools for Dementia and Mild Cognitive Impairment: AD8
Dementia and mild cognitive
impairment (MCI) are underrecognized in community settings. This may be due in
part to the lack of brief dementia screening tools available to clinicians. We
compared 2 brief, informant-based screening tests: the AD8 and the Informant
Questionnaire on Cognitive Decline in the Elderly (IQCODE) in a community-based
neurology practice in the midwestern United States.
Associated With Route Learning in Alzheimer Disease, MCI, and Normal Aging
The background of route
learning (RL) abilities in Alzheimer disease (AD), mild cognitive impairment
(MCI), and normal aging needs further study. We searched for neuropsychological
and demographical predictors of RL impairment.
Validation and Diagnostic
Utility of the Dementia Rating Scale in a Mixed Dementia Population
The Dementia Severity
Rating Scale (DSRS), a previously validated caregiver-based measure assessing
dementia severity, was recently revised to improve clarity. Our study aims
included: (1) identifying the DSRS factor structure, (2) examining the relation
between neuropsychological measures, the Mini-Mental State Examination, and
clinical diagnoses with the DSRS, and (3) determining the clinical utility of
the DSRS in a mixed clinical sample. A total of 270 veterans were referred to a
cognitive disorders clinic at a VA medical center and completed neuropsychological,
affective, and cognitive screening measures. p. p. 168-174
Life Enhancing Activities for
Family Caregivers of People With Frontotemporal Dementia
Aberrant psychological and
behavioral symptoms are common in patients with dementia. These symptoms have
negative consequences for family caregivers, causing stress and burden.
Frontotemporal dementia (FTD) symptoms cause more pronounced stress and burden
on caregivers than those associated with Alzheimer dementia. In this
randomized, attention control pilot study, we delivered 5-weekly, one-on-one,
positive affect intervention sessions to family caregivers of people with FTD.
The program, Life Enhancing Activities for Family Caregivers: LEAF was
conducted in-person or by videoconference with caregivers across the United
Demographic and Neuropsychiatric
Factors Associated With Off-label Medication Use in Frontotemporal Dementia and
Off-label medication use
for treating cognitive impairments and neuropsychiatric symptoms occurs in
frontotemporal dementia (FTD) and Alzheimer disease (AD). We compared the use
of cognitive and psychiatric medications in FTD and AD and evaluated the relationship
between neuropsychiatric symptoms and medication use.Cognitive and psychiatric
medication use, demographic variables, and Neuropsychiatric Inventory (NPI)
subscale symptoms were obtained from the National Alzheimer’s Coordinating
Center Uniform Data Set (n=3958, 8.1% FTD). Bivariate statistics and logistic
regressions were calculated to evaluate which demographic or NPI subscale
symptoms predicted medication use.
Novel TARDBP Sequence Variant
and C9ORF72 Repeat Expansion in a Family With Frontotemporal Dementia
degeneration (FTLD) is a genetically heterogenous syndrome and has been
associated most recently with a hexanucleotide repeat expansion within the C9ORF72
gene. Pathogenic TDP-43 gene (TARDBP) mutations have been identified in
amyotrophic lateral sclerosis, but the role of TARDBP mutations in FTLD
is more contradictory. To investigate the role of TARDBP mutations in a
clinical series of Finnish FTLD patients, we sequenced TARDBP exons 1 to
6 in 77 FTLD patients.
Olfactory Deficit and
Hippocampal Volume Loss for Early Diagnosis of Alzheimer Disease: A Pilot Study
The aim of this pilot study
was to verify the role of olfactory test and volumetric magnetic resonance
imaging measure of hippocampus to predict conversion from mild cognitive
impairment to Alzheimer disease (AD).